Aspiring Physician-Scientist · DO Track

From the bench to the bedside.

I am Jimmy Alexis, a biotechnology researcher and clinical professional with over ten years in patient care, working toward therapies for Alzheimer's disease, type 2 diabetes, and tumor-based cancers.

B.S. Biotechnology · UMGC 10+ years in patient care 3 published preprints ORCID verified
Review my research ↗ Open to shadowing & volunteering
Portrait of Jimmy Alexis, biotechnology researcher and clinical professional based in Bellefonte, Pennsylvania Bellefonte, PA
10+
Years in care
Statement of Purpose

My goal is to become a physician-scientist — translating discoveries at the bench into treatments at the bedside, and confronting the diseases that resist easy answers: neurodegeneration, metabolic disease, and solid tumors.

Experience

A decade of care, building toward the laboratory.

Each clinical role has deepened my understanding of disease and strengthened my commitment to patients.

2025 — Present

Clinical Professional

Mount Nittany Medical Center · Bellefonte, PA

Delivering direct patient care while advancing biotechnology studies and independent research.

Jan – Jul 2025

CNA-T · Cardiothoracic Stepdown & ICU

Lee Health · Fort Myers, FL

Provided high-acuity care across cardiothoracic stepdown and ICU units. Certified EKG Technician with seven additional clinical competencies.

Mar – Dec 2024

Volunteer Research Assistant

Fox Chase Cancer Center · Philadelphia, PA

Contributed to cancer stem cell research, including micropipetting, cell culture, and laboratory workflows in an oncology setting.

2023 — 2026

Resident Care Assistant

Delaware Valley Residential Care · Warminster, PA

Cared for patients with traumatic brain injuries — a formative experience that anchored my interest in neurodegeneration.

Education

Academic path.

In progress

B.S. Biotechnology

University of Maryland Global Campus. Coursework spanning molecular biology, biochemistry, and laboratory methods. Expected completion in progress since 2024.

Planned

Medical Degree · MD / DO

Intended next step. Shadowing physicians and scientists to inform specialty selection, with an interest in neurology and oncology.

Planned

Ph.D. · Immunology & Virology

Pursued following residency, completing the physician-scientist path and enabling independent translational research.

Published Research

Frameworks for complex disease.

Open-access preprints integrating published evidence into mechanistic, multimodal therapeutic hypotheses across oncology, neuroscience, and metabolic science.

Preprint · Oncology Published July 8, 2026 Open Access

Coupling Metabolic Niche Normalization with Reinstatement of the NR2F1 Dormancy Program: A Mechanistic Hypothesis for Durable Non-Chemotherapeutic Control of Breast Cancer Metastasis

A mechanistic hypothesis for durable, non-chemotherapeutic control of breast cancer metastasis, combining two complementary strategies: metabolic niche normalization through inhibition of the monocarboxylate transporters MCT1 and MCT4, and pharmacological reactivation of the NR2F1 dormancy program. The work proposes that metastatic outgrowth is governed by a metabolic–epigenetic switch, and that normalizing the acidic, lactate-rich tumor microenvironment while reinstating NR2F1-mediated dormancy may stabilize disseminated tumor cells in long-term quiescence. It integrates published evidence into a unified framework and sets out falsifiable predictions for testing in cell lines, organoids, and animal models.

Therapeutic Target
Breast Cancer Metastasis
Mechanism
MCT1 / MCT4 Inhibition
Dormancy Program
NR2F1 Reactivation
License
CC BY 4.0
Breast cancer Metastasis NR2F1 Lactate metabolism Tumor dormancy
DOI 10.5281/zenodo.21270368 Read full paper ↗
Preprint · Neuroscience Published Dec 3, 2025 Open Access

Neurotrophic Reprogramming Cocktail (NRC) for Alzheimer's Disease: A Conceptual Neuroregenerative Reset Framework

A conceptual multimodal framework designed to reverse Alzheimer's neurodegeneration through neuronal replacement, synaptic regeneration, and trophic support. It integrates neurotrophic factors (BDNF, NGF, GDNF), astrocyte-to-neuron reprogramming molecules (NeuroD1, Ascl1), and a PEG-PLA nanoparticle delivery system for targeted brain penetration and sustained release, with the objective of restoring functional circuits in hippocampal and cortical regions.

Therapeutic Target
Alzheimer's Disease
Delivery System
PEG-PLA Nanoparticles
Core Agents
BDNF · NGF · GDNF
License
CC BY 4.0
Astrocyte-to-neuron Nanodelivery Neurotrophins Neuroregeneration
DOI 10.5281/zenodo.17806213 Read full paper ↗
Preprint · Metabolic Disease Published Nov 24, 2025 Open Access

Preliminary Evaluation of a Multi-Compound Nutraceutical Strategy for Supporting Glucose Homeostasis in Type 2 Diabetes: A Mechanistic Analysis

A preliminary mechanistic analysis evaluating how a combined, multi-compound nutraceutical approach may support glucose homeostasis in type 2 diabetes — bridging biochemical pathways with practical, accessible metabolic support, and establishing a rationale for further investigation.

Therapeutic Target
Type 2 Diabetes
Focus
Glucose Homeostasis
Approach
Multi-Compound Nutraceutical
Type
Mechanistic Analysis
Glucose homeostasis Mechanistic Nutraceuticals T2DM
DOI 10.5281/zenodo.17705629 Read full paper ↗
Current Research

Questions under active investigation.

In progress

Melittin for Tumor Lysis

Evaluating melittin, the active peptide in bee venom, as a targeted agent to lyse tumor cells and a potential complement to conventional chemotherapy.

In progress

Mechanisms of Pain Sensitivity

Examining the biological and neural mechanisms that shape how individuals perceive and process pain.

In progress

The Biology of Stress

Studying how stress affects the body and brain, including its physiological pathways and downstream impact on health and disease.

Areas of Focus

Where I intend to make an impact.

Neurodegeneration

Reversing Alzheimer's disease through neuronal replacement, cellular reprogramming, and targeted brain-penetrant delivery.

Metabolic Disease

Supporting glucose homeostasis in type 2 diabetes through mechanistic, multi-compound strategies.

Tumor-Based Cancers

Building on cancer stem cell research to target the mechanisms behind solid tumors and metastatic recurrence.

0
Years in patient care
0
Research preprints
0
Certifications earned
0
Degrees in progress
Certifications

Trained, certified, and research-ready.

Academic Degrees

  • B.S. BiotechnologyUniversity of Maryland Global Campus2024 →
  • Medical Degree · MD / DOIntended next stepPLANNED
  • Ph.D. · Immunology & VirologyFollowing residencyPLANNED

Research & Clinical Training

  • Good Clinical Practice (GCP)NIDA Clinical Trials Network2025
  • Human Subjects Research (HSR)CITI Program2025
  • Human Gene Transfer TrialsCITI Program2025
  • Biomedical Research · Basic / RefresherCITI Program2025
  • Animal BiosafetyCITI Program2025
  • Drug Development: Bench to BedsideJohns Hopkins University2025
  • Epidemiology for Public HealthImperial College London2025
  • Basic Life Support (BLS)American Heart Association2025
  • Algae BiotechnologyUC Cooperative Extension2025
Open to Collaboration

Seeking to learn and gain experience.

I am actively seeking opportunities to shadow physicians and scientists and to contribute as a research volunteer. If our interests align, I would welcome the chance to learn from your work.

xtjimmy2167@gmail.com ↗ Connect on LinkedIn